We also analyzed kidney fibrosis after Nrf2 knockdown, and the results showed that STZ-induced DM caused visible fibrosis, increased glycogen deposition, TGF-β/Smad pathway activation, and the secretion of collagen I and collagen III, all of which were alleviated by Myr treatment after Nrf2 knockdown (Figure 6A–H). Here, TGFB1 is linked to fibrosis.