For example, during reactive astrogliosis, an event well described in both aged and AD brains (Scuderi et al., 2014a; Steardo et al., 2015; Rodríguez-Arellano et al., 2016), astrocytes modify their structure, usually studied by detecting the cytoskeletal glial fibrillary acidic protein (GFAP) and connexin expression (Peters et al., 2009; Giaume et al., 2010). This evidence concerns the gene GFAP and Alzheimer disease.