Splenocyte apoptosis has been shown to be relevant in human sepsis and treatments that target immune cell apoptosis improve survival (Hotchkiss et al., 2001) We have previously reported that Hamp causes splenic iron retention and H-ferritin induction under settings of ischemic AKI (sterile AKI) and is associated with reduced inflammation (Scindia et al., 2015). Here, FTH1 is linked to Sepsis.