Through bioinformatics, four major molecular pathways involved in cancer progression were seen to be affected, including PI3K-Akt signaling, ECM/receptor interaction, neurotrophin pathway, and focal adhesion, which leads to the apoptosis of cancer cells through the overexpression of apoptosis regulators NGFR and Bax genes (Li et al., 2017b). Here, BDNF is linked to cancer.