In HD, ER calcium homeostasis has been identified in patient-derived iPSCs, which could contribute to protein misfolding (Nekrasov et al., 2016), and increased levels of UPR effectors BiP and CHOP have been observed in HD patients (Carnemolla et al., 2009; Kalathur et al., 2015). The gene discussed is HSPA5; the disease is Huntington disease.