Increased BiP expression in neurons of AD patients (Hoozemans et al., 2005) Increased CHOP leads to proapotosis in AD (Lee et al., 2010) Reduction of PERK rescues memory and cholinergic neurodegeneration (Devi and Ohno, 2014) Excessive eIF2α phosphorylation associated with memory loss in models of AD (Costa-Mattioli et al., 2009; Ma et al., 2013; Trinh and Klann, 2013). The gene discussed is EIF2AK3; the disease is Alzheimer disease.