Previous studies have shown that genetic mutations play important roles in the pathogenesis of the sporadic form of PD, including SNCA, Parkin, PINK1, DJ-1, and LRRK2, in which SNCA is one of the most prominent hallmarks (Houlden and Singleton, 2012; Han et al., 2015; Tatura et al., 2016). This evidence concerns the gene SNCA and Parkinson disease.