MAPT and tauopathy: However, PP-Tau has been evidenced not only in tauopathy subjects, but also in hamsters during torpor (Arendt et al., 2003), as well as in mice (facultative hibernators; Hudson and Scott, 1979) exposed to different physiological challenges, such as starvation (Yanagisawa et al., 1999; Planel et al., 2001), cold water stress (Okawa et al., 2003), or general anesthesia (Planel et al., 2007).