MAPT and Alzheimer disease: In certain conditions and hyperphosphorylation states that are still largely unknown, monomers of Tau aggregate in oligomers that, either by coalescing in neurofibrillary tangles (NFT) or spreading as neurotoxic agents, characterize a group of disorders defined as tauopathies, ranging from Alzheimer’s disease (AD) to neurodegenerative pathologies (Gerson et al., 2016; Kovacs, 2017).