ANK1 and Alzheimer disease: In this study, we have characterized the first animal model based on mis-expression of the AD EWAS nominated ANK1 gene ortholog in Drosophila. Altered DNA methylation of human ANK1 occurs in AD brains, especially in regions that show gross AD pathology, such as the entorhinal cortex (De Jager et al., 2014; Lunnon et al., 2014).