We have investigated ANK mis-expression and compared its AD relevant phenotypes to Drosophila models expressing either (a) human mutant APP (which results in an aggregating form of oligomerized Aβ42), (b) MAPT (resulting in 0N4R Tau), (c) APP (Aβ42) with MAPT (0N4R Tau), and (d) APP (Aβ42) or MAPT (0N4R Tau) with Ank mis-expression, finding that mis-expression of these AD associated genes cause similar reduction in lifespan, movement, memory and neuronal excitability. The gene discussed is APP; the disease is Alzheimer disease.