We know that Ankyrins are adaptor proteins that attach to integral membrane proteins such as the Na+/K+ ATPase, voltage-gated Na+ (Nav1), voltage-gated K+ (KCNQ) and TrpA1 channels, and then link them to the actin-spectrin based membrane cytoskeleton, with some of these molecules having been associated with AD (Bennett and Baines, 2001; Yamamoto et al., 2007; Smith and Penzes, 2018). This evidence concerns the gene TRPA1 and Alzheimer disease.