We also found a reduction in locomotion in flies expressing human mutant APP (Aβ42), MAPT (0N4R Tau) and reduced Ank2. Interestingly, a recent study has shown that ANK1 hypermethylation is observed in PD, a movement disorder, that can also be associated with dementia (Smith et al., 2019). Here, ANK1 is linked to dementia.