However, as FUS aggregation in the hippocampal area is an FTD characteristic, while in ALS pathology a similar accumulation is seen in motoneurons (Nolan et al., 2016), it is thus relevant in an ALS context, to study FUS localization specifically in healthy motoneurons and compare it to those harboring a FUS mutation. The gene discussed is FUS; the disease is frontotemporal dementia.