In healthy adult tissue TrkC.T1 is low or undetectable, but it is significantly upregulated shortly after injury, but before degeneration and detectable symptoms, in neurodegenerative diseases such as glaucoma, RP, and ALS (Bai et al., 2010b; Brahimi et al., 2016; Galán et al., 2017b), as well as in noise-induced hearing loss (Saragovi, unpublished). The gene discussed is NTRK3; the disease is amyotrophic lateral sclerosis.