Published small molecule inhibitors of TrkC (Brahimi et al., 2010, Brahimi et al., 2014, 2016; Liu et al., 2010) are non-selective between TrkC-FL and TrkC.T1, but significantly decrease TNFα levels and neuronal cell death in a mouse model of glaucoma (Bai et al., 2010b). This evidence concerns the gene NTRK3 and glaucoma.