NTRK1 and amyotrophic lateral sclerosis: With respect to translation to clinical use, one of our TrkA-selective small molecule agonists is currently in Phase 3 clinical trials for an ophthalmic indication, a TrkC-selective mAb agonist is in pre-clinical studies for ALS, and Trk-selective agonistic mAbs and NT mutants are under investigation for neurosensory hearing loss.