MTOR and Cerebral ischemia: Liu et al. (2018b) report that activation of autophagy flux in astrocytes might conduce to neural recovery mechanisms and endogenous neuroprotective following stroke. Nampt promotes neuronal survival via inducing autophagy by modulating the TSC2-mTOR-S6K1 signaling pathway in a SIRT1-reliant manner during cerebral ischemia (Wang et al., 2012).