(Xu et al. (2017) reported that the neuroprotection of L-3-n-Butylphthalide (L-NBP) in attenuating learning and memory deficits in mice after repeated cerebral ischemia-reperfusion (RCIR) might be associated with the modulation of the expressions of proteins involved in apoptosis and autophagy and the promotion of Akt/mTOR signaling pathway. Here, MTOR is linked to brain ischemia.