Mutations in cyclin F (CCNFS621G), which cause rare familial cases of ALS/FTD, have also been studied by overexpression in neuronal cell lines and zebrafish to investigate the effects and mechanisms of ALS/FTD (Williams et al., 2016; Hogan et al., 2017; Lee A. et al., 2018). This evidence concerns the gene CCNF and frontotemporal dementia.