Pathological phosphorylation of proteins such as tau, TDP-43, α-synuclein or FUS contribute to the formation of protein inclusions in neurodegenerative disease (Hasegawa et al., 2008; Despres et al., 2017; Monahan et al., 2017; Cykowski et al., 2018). Here, TARDBP is linked to neurodegenerative disease.