C9orf72 and amyotrophic lateral sclerosis: Zfp106 interacts with hexanucleotide repeat (GGGGCC) RNA-binding protein, other RNA-binding proteins: TDP-43 and FUS. Zfp106 KO mice develop motor neuron degeneration. Zfp106 suppresses neurotoxicity in Drosophila C9orf72 ALS model