ESR1 and neoplasm: PFKFB4 had an HR of 7.38 (95% CI 1.69–32.3; p = 0.008) and retained prognostic power (HR 7.44, 95% CI 1.67–33.2; p = 0.009) when adjusted by tumor size, lymph node status, grade, ER status, HER2 status and subtypes.