The recent studies showed that TMPRSS4, which is kind of TTPs family and frequently overexpressed in the cancer cells (Kim et al.,2014; Chikaishi et al., 2016; Wu et al., 2014; Liang et al., 2013; Cheng et al., 2013), function as a cancer treatment target biomarker through the use of Cancer gene therapy (CGT) strategies. Here, TMPRSS4 is linked to cancer.