As it has been reported in our previous studies that UBE2D3 is negatively correlated with cell proliferation and telomere maintenance (Wang et al., 2013;Yang et al., 2016) and cell proliferation has been inhibited by affecting telomere integrity via silencing of POT1 (Lei et al., 2015;) and TPP1 (Yang et al., 2013), the present study suggest that TMPRSS4 modulation modulates cell proliferation by modulating telomere maintenance in breast cancer cells. The gene discussed is UBE2D3; the disease is breast cancer.