As it has been reported in our previous studies that UBE2D3 is negatively correlated with cell proliferation and telomere maintenance (Wang et al., 2013;Yang et al., 2016) and cell proliferation has been inhibited by affecting telomere integrity via silencing of POT1 (Lei et al., 2015;) and TPP1 (Yang et al., 2013), the present study suggest that TMPRSS4 modulation modulates cell proliferation by modulating telomere maintenance in breast cancer cells. This evidence concerns the gene TPP1 and breast cancer.