BCL2 and cancer: The pro-apoptotic (Bax) and anti-apoptotic (Bcl2) proteins are key proteins in the signaling pathway of cell apoptosis and are also used as a therapeutic target for cancer treatment via apoptotic pathway affection (Akl et al., 2016; Adams et al., 2018; Pawlowski et al., 2000; Xin et al., 2014).