NPM1 and acute myeloid leukemia: These findings are lower than reported among CN-AML in German (31 to 32% FLT3-ITD, 11 to 14% FLT3-D835 , 45.7 to 53% NPM1) (Frohling et al., 2002; Schlenk et al., 2008; Thiede et al., 2006), United States (34.6% FLT3-ITD, 7.4% FLT3-D835) (Whitman et al., 2008), United Kingdom (34% FLT3-ITD, 62% NPM1) (Gale et al., 2008) and Japan (47.4% NPM1) (Suzuki et al., 2005).