TP53 and cervical carcinoma: Thus, restoration of p53 function is crucial in the management of HPV-associated cervical cancer because HeLa cells were treated with celecoxib (non-steroidal anti-inflammatory drug) could re-activate p53 via induction of ataxia telangiectasia mutated-/p38 mitogen-activated protein kinase and down regulation of cycloxygenase-2 (Saha et al., 2012).