BRCA2 and breast carcinoma: Based on these factors, this study aimed to compare hereditary breast tumors with and without BRCA1 and BRCA2 pathogenic variants, with those carrying BRCA1 and BRCA2 variants of unknown significance (VUS) and with patients with sporadic breast cancer regarding to the family history of cancer, as well as with histopathological and imunnohistochemical tumor characteristics.