For BRCA2, there were no variables in the family history or tumor profile conferring a significative higher risk to be a carrier, highlighting how different the tumors of individuals carrying germline mutations in BRCA1 and BRCA2 are, in spite of their association with the same cancer predisposition syndrome, HBOC and which are the main differences and similarities between them. This evidence concerns the gene BRCA1 and neoplasm.