While Neumann et al. showed that higher expression of SOX2 at the site of primary tumor correlate with poorer prognosis and lymph node metastasis (Neumann et al., 2011), others demonstrated a significant correlation between increased expression of SOX2 and the absence of lymph node metastasis (Züllig et al., 2013). Here, SOX2 is linked to metastatic malignant neoplasm in the lymph nodes.