In this study, we measured the expression level of miR-200c, miR-9 and their target genes ZEB1, ZEB2 and E-cadherinin patients with NSCLC.These patients were investigatedby the changes in miRNAsexpression level in tumor and normal tissues and the link between their expression levels with their target genes at mRNA level were analyzed. The gene discussed is ZEB1; the disease is neoplasm.