This report encompasses the genetic association study carried out on the association of inflammatory response genes polymorphisms such as TNF-α -308 G>A, ICAM-1 K469E, ICAM-1 R241G , IL-6 -174 G>C , PPAR-γ 34 C>G, and also including IL-8 -251 T>A, with susceptibility risk in Malaysian CRC patients. The gene discussed is TNF; the disease is colorectal carcinoma.