IL18 and Familial prostate cancer: In conclusion, the present meta-analysis provides information that there is no association between IL-18 -607 C/A polymorphism and prostate cancer risk in the overall population, but in the stratified analysis by ethnicity, IL-18 -607 C/A polymorphism was found to be associated with prostate cancer risk as a protect factor in the Asian population and also associated with prostate cancer risk in Caucasians.