Here, we analyzed data from 3,055 postmenopausal samples from a large cross‐sectional survey that enrolled more than 10,000 Chinese individuals, showing that high circulating FSH level increased the risks of decreased eGFR and CKD in the postmenopausal female population, and this positive correlation was independent of age, total T, estradiol, current smoker status, etc. Based on large‐scale clinical data analysis, we attempted to investigate whether FSH participated in the progression of kidney disease in experimental study. Here, BRD2 is linked to kidney disorder.