PLOD1 and metabolic syndrome: After adjusting for age, total testosterone (T), E2, LH, current smoker status, urban/rural residence, high/low economic status, BMI, dyslipidemia, diabetes, and hypertension, the odds risks (ORs) of decreased eGFR (OR = 3.04, 95% CI: 2.17–4.27) and CKD (OR = 2.76, 95% CI: 1.50–5.06) in the highest quartile of FSH increased approximately threefold compared with that in the lowest quartile (p for trend <0.001, Figure 1d,e), respectively.