Previous studies showed that epithelium-specific integrin αvβ6–mediated EMT was involved in pulmonary fibrosis via transforming growth factor-β1 (TGF-β1) signaling, but whether integrin αvβ6 plays a role in the P. aeruginosa–associated airway remodeling remains unknown. The gene discussed is TGFB1; the disease is pulmonary fibrosis.