Importantly, prevention of TRAF3 degradation by the autophagolysosome inhibitor, chloroquine, inhibits RANKL-induced osteoclast formation in vitro and prevents PTH-induced osteoclastogenesis and ovariectomy-induced osteoporosis in mice14, suggesting that inhibition of TRAF3 degradation in OCPs could prevent osteoporosis in humans. Here, TNFSF11 is linked to osteoporosis.