Our analysis of RNA-seq data generated from 54 B-ALL pediatric patient samples with IGH@ translocation showed that SV breakpoints on IGH-DUX4 and IGH-CRLF2 translocation were highly enriched on IGH D-J junctions (red box on Supplementary Fig. 6) while expression of the target oncogenes, i.e., DUX4 (Fig. 1) and CRLF2 (Supplementary Fig. 7, data are from published paper17,28) is significantly lower than that of Igμ—both patterns match what we observed in Nalm6. This evidence concerns the gene DUX4 and acute lymphoblastic leukemia.