Again, we observed that the relative expression level of GRP78 to SPARC may be a better indicator of CRC cells’ response toward chemotherapy: while the most resistant HT29 has the highest ratio of GRP78 to SPARC expression level, the most sensitive HCT116 also shows the lowest relative expression level among the three (Fig. 3e, right panel). Here, SPARC is linked to colorectal carcinoma.