In particular, Cc-A1AT provided 50% protection from HIV-1 infection in BLT mice and provided an 86% increase in survival following vaginal infection in C56BL/6 mice, whereas Cc-griffithsin provided 75% protection from HIV-1 infection and 57% protection from HSV-2 disease (13). This evidence concerns the gene CXCR1 and HIV-1 infection.