Three additional recombinants were able to provide significant protection from vaginal infection in BLT mice: Cc-GBVCE2, recombinant C. crescentus bacteria expressing elafin (Cc-elafin), and recombinant C. crescentus bacteria expressing α-1-antitrypsin (Cc-A1AT). This evidence concerns the gene CXCR1 and infective vaginitis.