IDH2 and astrocytoma (excluding glioblastoma): Nowadays, these tumors are classified according to the 2016 WHO system by both histologic and molecular characteristics as IDH-mutant or IDH-wildtype astrocytomas; IDH-mutant and 1p19q-codeleted oligodendrogliomas; and IDH-mutant or IDH-wildtype glioblastomas [5].