IDH1 and glioblastoma: In previous studies and by using transduced malignant glioma cell lines U-251MG (glioblastoma) U-343MG (anaplastic astrocytoma) and LN-229 (glioblastoma) we showed that gene expression of mutated IDH1 (IDH1R132H) resulted in elevated radiosensitivity [41,42,43].