MAPT and tauopathy: For instance, in a mutant human tauopathy Drosophila melanogaster model (R406W), the following features were observed: Abnormal accumulation and aggregation of F-actin, CFL1--actin rods co-localized with phosphorylated tau, and in vitro incubation of F-actin with bovine tau generated bundling of F-actin [109].