In this regard, the expression of several miRNAs was induced and these miRNAs were secreted in exosomes by tumor cells following epigenetic treatment using 5’ AZA and the addition of trichostatin A. In particular, tumor-derived exo-miR-512 and miR-373 were both associated with cisplatin sensitivity and the suppression of tumor progression in cultured lung cancer cells through the direct downmodulation of TEAD4, RelA, and PIK3CA [55]. The gene discussed is PIK3CA; the disease is neoplasm.