GAA and type 2 diabetes mellitus: The phlorotannin, dieckol, isolated from brown seaweed, was found to inhibit alpha-glucosidase activity in vitro [13], and to protect against the glucotoxicity-induced oxidative stress associated with diabetes [14,15], delay T2D development in a db/db mouse model [16], and reduce postprandial hyperglycemia in prediabetic subjects [17].