It is an auxiliary receptor for the members of the transforming growth factor-β (TGF-β) family, and a role for endothelial endoglin in pathological conditions involving the vasculature, including hereditary hemorrhagic telangiectasia type 1 (HHT1), preeclampsia, and cancer angiogenesis, has been described [38,39,40,41]. The gene discussed is ENG; the disease is cancer.