In this manuscript, we report a new link between pro-inflammatory GM-MΦ and endothelial cells, by which GM-MΦ-derived MMP-12 targets membrane bound endothelial endoglin, leading to the release of sEng, a soluble protein with pro-inflammatory properties and the potential to promote endothelial dysfunction in combination with hypercholesterolemia [55]. Here, ENG is linked to endothelial dysfunction.