Numerous recent studies have demonstrated a relationship between coronary atherosclerosis and OPG levels [9] or between coronary atherosclerosis and 25-OH-D3 levels [17], but no study has associated these biomarkers of arterial stiffness with RRI, an indicator of renal vascular damage common in heart failure patients [16]. This evidence concerns the gene TNFRSF11B and coronary atherosclerosis.