The randomized phase II SHINE study (NCT01457846) investigated whether AZD4547 improved clinical outcome versus paclitaxel as a second-line treatment in patients with advanced gastric adenocarcinoma displaying FGFR2 polysomy or gene amplification detected by fluorescence in situ hybridization (FISH). This evidence concerns the gene FGFR2 and gastric adenocarcinoma.