ATF6 and neurodegenerative disease: In the current study we identified dysregulated expression of several members of the ZNF family, including ZNF704, which is a suggested potential candidate gene for healthy ageing [48], and ATF6, a member of the leucine zipper family of transcription factors which plays a major role in regulating tissue homeostasis in response to stress [49], and is expressed at high levels in a range of neurodegenerative diseases including amyotrophic lateral sclerosis [50].