In our cohort of a 1000 HCs only 8.3% were homozygous for the protective allele (C) for SNP rs2104286 and therefore we were not able to reproduce findings in a secondary cohort and it was only possible to determine the combined association of the MS-associated SNPs rs2104286 and rs11256593 and not the independent associations of the rs2104286 and rs11256593 SNPs on expression of CD25 without compromising the size and pairing of the genotype groups. The gene discussed is IL2RA; the disease is myeloid sarcoma.