Furthermore, such studies could also provide new insight to if and how MS-associated IL2RA SNPs contribute to the impaired suppressive capacity of CD39+ TReg cells [33], the reduced frequency of CXCR5+ TFH1 cells [37] and the promotion of pro-inflammatory CD4+ T cells observed in MS patients [31]. This evidence concerns the gene CXCR5 and myeloid sarcoma.