For example, some of the differentiation proteins, such as SERPINA3 and CRP involved in inflammatory/acute-phase response, as well as FGA and PLG involved in blood coagulation, were associated with the cardioembolic, large-vessel, and lacunar ischemic stroke subtypes, but not with CBS deficiency (Table 3). The gene discussed is PLG; the disease is hyperinsulinemic hypoglycemia, familial, 4.