The majority of proteins affected in the ischemic stroke subtype comparisons are involved in acute phase response (SAA1, CRP, SERPINA3, SERPINA1, LBP, ORM1, AHSG), immune/inflammatory response (APC, C4BPA, IGK, IGKV1V-12, PGLYRP2), blood coagulation (A2M, FBLN1, FGA, PLG, SERPIND1, F13B, etc.), and cholesterol transport/metabolism (APOC1, APOC3, APOL1, etc.)(Table 3). The gene discussed is A2M; the disease is ischemic stroke.