Beyond the observed dysregulation of adipogenesis, others reported that male GPER1 KO mice developed hyperinsulinemia and hyperglycemia by 18 months of age (Sharma et al. 2013) and female GPER1 KO mice developed impaired glucose tolerance within 6 months of age (Martensson et al. 2009). This evidence concerns the gene GPER1 and Hyperinsulinemia.