Since the activation of mitogen-activated protein kinase (MAPK) cascades has shown to play a key role in pancreatic cell proliferation, differentiation, migration, senescence, and apoptosis [30,31] as well as in the tumorigenesis of pancreatic cancer, we next examined whether the phosphorylation of ITGB4 at Y1510 is involved in the regulation of MAPK signaling cascades. Here, WNK2 is linked to familial pancreatic carcinoma.