WNK2 and pancreatic neoplasm: Since the activation of mitogen-activated protein kinase (MAPK) cascades has shown to play a key role in pancreatic cell proliferation, differentiation, migration, senescence, and apoptosis [30,31] as well as in the tumorigenesis of pancreatic cancer, we next examined whether the phosphorylation of ITGB4 at Y1510 is involved in the regulation of MAPK signaling cascades.