To further investigate whether the phosphorylation of ITGB4 was associated with the tumorigenicity of pancreatic cancer, we analyzed p-ITGB4-Y1510 expression in the tissue specimens from local invasion and distant metastasis and compared with the expression of p-ITGB4-Y1510 in normal tissues. The gene discussed is ITGB4; the disease is familial pancreatic carcinoma.