The inhibition of phosphorylation of ITGB4 at Y1510 in pancreatic cancer PC-1.0 and AsPC-1 cells significantly decreased the level of p-MEK1 (T292) and p-ERK1/2 but did not affect the level of p-MEK1 (T386) and p-MEK2 (T394). Here, MAP2K2 is linked to familial pancreatic carcinoma.