While kidneys from WT mice displayed limited and predominantly dispersed chronic inflammation with sparse neutrophils 6 days post-infection, kidneys from Dectin-1-Dectin-2 DKO and Mincle-Dectin-2-Dectin-1 TKO1 mice displayed extensive mixed inflammation affecting the cortex, medulla and renal pelvis with focal extension into surrounding adipose tissue (Fig 2F–2H). Here, CLEC4E is linked to infection.