We observed increased numbers of myeloid cells including Ly6Chi monocytes/macrophages and neutrophils in the kidneys of Dectin-1-Dectin-2 DKO and Mincle-Dectin-2-Dectin-1 TKO1 mice compared to WT mice as early as 20 h post-infection (S3 Fig) and also at 4 days post-infection (Fig 2A). The gene discussed is CLEC4E; the disease is infection.