Consistent with previous studies, the majority of genes that are preferentially overexpressed after exposure to IL-2 are involved in cell-to-cell signaling, whereas CTV-1 stimulation upregulated the expression of genes that are specifically associated with NK cell cytotoxicity against tumor targets (including STAT5A, MAP2K3, DUSP2/6) [24]. The gene discussed is MAP2K3; the disease is neoplasm.