We set out to determine the antigen expression profiles of peripheral blood-derived NK cells from healthy donors upon exposure to tumor targets or cytokines by incubating freshly-isolated cells in medium alone, with K562, CTV-1, Daudi, RPMI-8226, or MCF-7 tumor cell lines, the individual cytokines IL-2, IL-12, IL-15, or IL-18, or a combination of IL-12/15/18. This evidence concerns the gene IL18 and neoplasm.