We have also shown that tumor-priming NK cells induces the expression of NK cell activation markers such as CD69 and CD25; the secretion of pro-inflammatory cytokines, including MIP-1 α /β, RANTES, IL-6, IL-8, and IL-1β; and upregulation of numerous genes that are associated with enhanced NK cell cytotoxicity and immunomodulatory functions (including FAS, TNFSF10, CD80, MAPK11, TNF, IFNG, CCL3/4/8, and CXCL9/11). Here, TNF is linked to neoplasm.