While we did observe higher WNVE-specific IgG titers in MAVS-/- compared to WT mice following WNV-MAD infection (Fig 2A), consistent with observations previously reported with WNV-TX [9], we also observed elevated nAbs, GC B cells and TFH cells in the absence of MAVS (Fig 2B, 2D and 2E). This evidence concerns the gene MAVS and infection.