MAVS and infection: Finally, although the GCs in both WT and MAVS-/- mice contracted significantly over the course of a nine-week infection (S3C Fig), WNVE-specific IgG ASCs in the spleen and long-lived plasma cells (LLPCs) in the bone marrow (BM) were still significantly elevated in MAVS-/- mice versus WT at this time point (Fig 2F), mirroring serum IgG levels (Fig 2A).