P2RY12 and atherosclerosis: To explore the mechanism by which the P2Y12 antagonists CLO and TIC decreased atherosclerosis, we subjected the total RNAs from the aortae of mice on a HFD treated for 16 weeks with either nothing (CTL, N = 5), CLO (N = 5), or TIC (N = 5) to RNA-sequencing using NGS (Fig 5A).