PON1 and atherosclerosis: The most significant finding of the current study is that although CLO and TIC equally inhibited platelet aggregation (Fig 1A–1C, S1 Fig), TIC protected hypercholesterolemic mice against atherosclerosis more robustly than did CLO (Fig 2) likely through the induction and increased serum activities of PON1 (Fig 5A–5F).