Previously, we showed that intestine-specific caudal-related homeobox transcription factor CDX2 elements confer colon epithelium-preferential transgene expression in the adult mouse, and that mice carrying a CDX2P-NLS Cre recombinase transgene and a floxed Apc allele developed colorectal adenomas and carcinomas [26]. This evidence concerns the gene APC and carcinoma.