However, of the small subset of cholesterol biosynthesis-related transcripts implicated as being the most responsible for determining the specific tumor patterns (S8 Fig), namely HMGCS2, DHCR24 and PMVK, the former is a direct Myc target [59] and all three have individually been previously shown to be de-regulated in and correlated with survival in diverse cancer types [59, 61–65]. This evidence concerns the gene HMGCS2 and cancer.