SHMT2 and neoplasm: MC-HFD and LC-HFD tumor cohorts also significantly down-regulated (by 32% and 41%, respectively) transcripts encoding mitochondrial serine hydroxymethyl transferase 2 (Shmt2), the rate-limiting enzyme for glycine and 5,10-methylenetetrahydrofolate biosynthesis, with the latter also being an essential intermediate for purine anabolism [37] (Fig 2H and S1A Fig).