The CKD associated factors are either hemodynamic (volume overload, arteriovenous fistula and anemia) or metabolic, such as oxidative stress; inflammation; hyperhomocysteinemia; proteinuria; increased renin-angiotensin-aldosterone activity; abnormal calcium, phosphorus and vitamin D metabolism; increased serum FGF-23 levels; dyslipidemia; hypoalbuminemia; increased pro-thrombotic factor levels; endothelial dysfunction and infection (Chlamydia pneumoniae) 11. The gene discussed is FGF23; the disease is chronic kidney disease.