Dystroglycan is an extracellular peripheral membrane glycoprotein that helps maintain normal muscle function; evidence indicates that an increase in muscle-specific Dag1 ameliorates loss of the dystrophin-glycoprotein complex [31], and our data suggest that MICT counteracts age-related impaired muscle regeneration and muscular dystrophy by upregulating Dag1. This evidence concerns the gene ART4 and muscular dystrophy.