Our previous in vitro experiment found cigarette smoke extract could promote EBV lytic gene expression in B cells.21 Further, our previous large‐scale multicenter epidemiological study observed positive relationships between smoking and serum seropositivity for VCA‐IgA,21 EBNA1‐IgA and Zta‐IgA,22 as well as oral EBV DNA loads25 among healthy individuals, especially those in areas with high NPC incidence. The gene discussed is CD79A; the disease is nasopharyngeal carcinoma.