In previous studies, tumors with pathogenic exonuclease domain mutations in the POLE gene were reported to harbor extremely high TMB, with a characteristic nucleotide base substitution exhibiting increased C‐to‐A transversions.1, 7 Moreover, a recent study showed that POLE category CRC and EC had carcinogenic mechanisms distinct from those of other tumors,14 suggesting that POLE category tumors may exhibit distinct characteristics. Here, POLE is linked to colorectal carcinoma.