Signatures 6 and 10 were related to microsatellite instability and POLE exonuclease domain mutation, respectively.20 As shown in Figure 3B, the signature score of Signature 6 was significantly higher in common‐hypermutators than in POLE category tumors, and the signature score of Signature 10 was significantly higher in POLE category tumors than in common‐hypermutators, suggesting the validity of the current tumor classification. This evidence concerns the gene POLE and neoplasm.