In this study, we further investigated the express pattern of LINC00526 in larger glioma tissue samples, analysed its correlation with clinical features and prognosis, confirmed its biological roles in glioma progression and explored the potential molecular mechanisms mediating the dysregulation of LINC00526 in glioma and the mechanisms responding for the roles of LINC00526 in glioma. The gene discussed is LINC00526; the disease is central nervous system cancer.